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KMID : 0388120090180030102
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Journal of Korean Society for the Study of Obesity
2009 Volume.18 No. 3 p.102 ~ p.115
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Comparisons of 12 week combined exercise intervention-mediated changes of body composition, physical fitness, and metabolic syndrome risk factors according to IGF-I gene polymorphism in obese adolescent boys
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Ahn Na-Young
Kim Ki-Jin
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Abstract
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Background: The influence of Insulin-like growth factor I (IGF-I) has been considering the important factor for the changes of body composition, bone growth, cell proliferation and metabolism.
Methods: The study analyzed a polymorphism of the IGF-Ⅰ gene in the subjects who were composed of male middle-school students (N=21 in obese group, N=19 in non-obese group). Subjects were measured on body composition, blood profiles, and physical fitness. It was compared on the difference of body fitness performance and on the changes after the exercise intervention according to IGF-Ⅰ gene polymorphism.
Results: The frequency of 19 CA repeat was 62.5% in 2 branches allele on the whole of subjects, 71.4% on the obese group and 52.6% on the normal weight group. The results of IGF-1 gene polymorphism are as followed: the whole 19 CA repeat (192 bp allele) homozygous (n=5, 12.4%), heterozygous (n=20, 49.6%), non-carriers (n=15, 38%). Ratio of body fat on body composition in the genotype polymorphism inclined to be higher in homozygous group than heterozygous and non-carriers groups. There were no differences in the genotype polymorphism of grip strength (Right) and PEI, but there were an increase in non-carrier group. Body fat and HOMA-IR decreased in two groups, especially in the obese group after 12 weeks exercise intervention. Comparing to non-carriers group, there was an increase (p=0.033) in homozygous and heterozygous of the obese group in sit-up. There were no differences on the homozygous group of the obese on polymorphism of grip strength (Right), but there was a significant increase in the other groups. Body composition of homozygous groups increased in the IGF-Ⅰ gene polymorphism but the other groups didn’t.
Conclusion: Grip strength and sit-up improved in homozygous groups of the obese after 12 week exercise intervention. However, it is necessary to study further on the comparisons of effects of exercise intervention following to IGF-I gene polymorphism and to carry the studies out on more subjects.
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KEYWORD
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IGF-I polymorphism, adolescent, exercise intervention, body composition
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